Jitendra came to limelight in 1967 with Ravikant Nagaich's film Farz, which became a golden jubilee success of that time. He became a style icon, with the tee shirt and white shoes he wore for the song "Mast Baharon Ka Main Aashiq" in Farz, sung by Mohammed Rafi. For his intense and lively dance in films like Farz (1967), Humjoli (1970), and Caravan (1971) he was called the 'Jumping Jack of Bollywood'.
Few of Jintendra's landmark films are: Geet Gaya Pattharon Ne (1965) with Rajshri, Farz (1967) with Babita, Jeene Ki Raah (1969) with Tanuja, Humjoli (1970) opposite Leena Chandavarkar, Caravan (1971) opposite Asha Parekh, Parichay (1972) opposite Jaya Bhaduri, Bidaai (1974) with Leena Chandavarkar, Khushboo (1975) opposite Hema Malini, Dharamveer (1977) with Neetu Singh, Swarg Narak (1978) opposite Maushumi Chatterjee, Judaai (1980) opposite Rekha, Asha (1980) with Reena Roy, Himmatwala (1983) opposite Sridevi, Tohfa (1984) with Sridevi, Jaya Prada, Khudgarz (1987) opposite Bhanupriya and many more.
Jitendra recently did the role of a an old man in the popular TV serial Kyunki Saas Bhi Kabhi Bahu Thi, directed and produced by her daughter Ekta Kapoor. In 2002, Jitendra was given the Filmfare Lifetime Achievement Award, for his contribution to Indian cinema.