The ill effects of high uric acid levels

High Uric Acid Levels - Causes, Symptoms & Prevention

High Uric Acid Levels - Causes, Symptoms & Prevention

A 47-year-old man presents to the medical OPD with a highly painful swelling of his left big toe.  He says it developed over several hours, and has now reached a stage when even so much as putting a bedspread on the foot causes intense pain. He has had several such episodes in the past, each lasting for 7-10 days.  He is obese, has high BP, consumes non-vegetarian diet and drinks whisky regularly.

What is gout?

Sufferers of gout – called vat-rakta in Ayurveda – would immediately identify themselves with the gentleman and his problem described above.  This is because gout has a very typical presentation: single, intensely painful swelling of a joint (most commonly the base of the toe), recurrent in nature, and sometimes involving multiple joints.

What are the causes of high uric acid level?

Gout is the result of hyperuricemia – or raised uric acid levels in the blood.  Uric acid is a natural byproduct of food metabolism and tissue breakdown.  It is naturally eliminated through the kidneys.  However, in some individuals, uric acid may be overproduced, or not eliminated properly.  This results in the raised blood and tissue levels, leading to deposition of monosodium urate crystals under the skin, in joints and in kidneys.  This then manifests as tophi – deposits of crystals under the skin, painful arthritis or renal stones, respectively.  As seen in the scenario above, pain from gouty arthritis can be crippling, and result in loss of productivity for several days to weeks.

The following factors may predispose an individual to developing high uric acid levels, and consequently gout:

  • Middle aged men
  • Family history of gout
  • Obesity
  • High blood pressure
  • Diabetes
  • Kidney disease
  • Raised triglyceride level
  • Certain enzyme disorders
  • Lifestyle causes: over-indulgence of alcohol, non-vegetarian diet, salty, sugary and fatty substances, and lack of exercise and/or sedentary lifestyle 

What are the symptoms?

  • Painful joint swellings, which may be in one joint to begin with, and later involve many others
  • Sudden shooting pains in the lower back, radiating to the groin; due to a renal stone
  • Renal stone in turn may lead to nausea, vomiting and blood in the urine
  • Deposition of uric acid crystals under the skin causing tophi – or swellings on fingers, toes, hands and elbows

When is medical attention required?

If you have any of the predisposing factors listed above, and are having symptoms suggestive of gout, it is better to have this evaluated at the earliest.  Your physician, orthopedician or rheumatologist would be able to make a full assessment and order appropriate investigations to make the diagnosis. Although blood uric acid levels and X-ray of the affected joint would help, the definitive diagnosis can only be made by examining the aspirated fluid from the affected joint under the microscope to demonstrate the monosodium urate crystals.

What is the treatment?

Once it is diagnosed, non-steroidal anti-inflammatory drugs such as ibuprofen may be used to reduce the pain and inflammation. However, if you are asthmatic or have a history of peptic ulcer, these are better avoided.  Rarely, steroids may have to be used to control the symptoms.  Even though colchicine and allopurinol have been traditionally used to treat gout, newer drugs are available these days.  In extreme cases, especially if there is significant joint damage due to recurrent or chronic gout, surgical treatment may be necessary. Ayurvedic and herbal remedies are also available for gout.  Before undertaking any of these, it is always advisable to diagnose the condition accurately, since a number of other disorders are present with similar symptoms.

What can I do to reduce high uric acid level?

There are a host of things that you can do yourself to alleviate the symptoms of gout, and to reduce further attacks.  Here are a few:

  • Be regular with the medications and follow-up care
  • During an attack, keep the limb elevated, take adequate pain relieving medications, and apply ice packs to reduce the pain; cherry juice and apple cider vinegar are also said to relieve the pain
  • Drink up to 10 glasses of water a day to reduce the chance of dehydration and formation of urate crystals
  • Consume high fiber diet such as green leafy vegetables and fruits to increase the elimination of uric acid
  • Take antioxidant rich foods such as berries, grapes and pineapples
  • A number of foods are recommended as specific therapy for gout; these include bananas, apples, lime, vegetable juices (especially carrot, beetroot and cucumber), French beans, olive oil, and vitamins C and E

Preventive Measures:

  • Avoid excess consumption of alcohol, red meat, mushrooms, yeast extracts and oily fish, as these are known to elevate blood uric acid levels
  • Avoid excessively fatty, oily, salty and sugary substances
  • Undergo regular checkup of BP, sugar level, cholesterol status and renal parameters
  • Keep your weight under check by exercising regularly

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